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兒童血漿鳶尾素與肥胖關系的隊列研究

吳生池 陳亞軍 談敏怡 鮑文文 陳宇靖 梁景宏 章舒心 蔡莉

吳生池, 陳亞軍, 談敏怡, 鮑文文, 陳宇靖, 梁景宏, 章舒心, 蔡莉. 兒童血漿鳶尾素與肥胖關系的隊列研究[J]. 中國學校衛生, 2021, 42(10): 1536-1539, 1543. doi: 10.16835/j.cnki.1000-9817.2021.10.022
引用本文: 吳生池, 陳亞軍, 談敏怡, 鮑文文, 陳宇靖, 梁景宏, 章舒心, 蔡莉. 兒童血漿鳶尾素與肥胖關系的隊列研究[J]. 中國學校衛生, 2021, 42(10): 1536-1539, 1543. doi: 10.16835/j.cnki.1000-9817.2021.10.022
WU Shengchi, CHEN Yajun, TAN Minyi, BAO Wenwen, CHEN Yujing, LIANG Jinghong, ZHANG Shuxin, CAI Li. Association of plasma irisin concentration with obesity among children: a cohort study[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(10): 1536-1539, 1543. doi: 10.16835/j.cnki.1000-9817.2021.10.022
Citation: WU Shengchi, CHEN Yajun, TAN Minyi, BAO Wenwen, CHEN Yujing, LIANG Jinghong, ZHANG Shuxin, CAI Li. Association of plasma irisin concentration with obesity among children: a cohort study[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(10): 1536-1539, 1543. doi: 10.16835/j.cnki.1000-9817.2021.10.022

兒童血漿鳶尾素與肥胖關系的隊列研究

doi: 10.16835/j.cnki.1000-9817.2021.10.022
基金項目: 

廣東省自然科學基金面上項目 2019A1515011462

國家自然科學基金面上項目 81673193

詳細信息
    作者簡介:

    吳生池(1996-),女,重慶開州人,在讀碩士,主要研究方向為兒童體質健康

    通訊作者:

    蔡莉,E-mail: caili5@mail.sysu.edu.cn

  • 中圖分類號: R723.14 R446 G627.8

Association of plasma irisin concentration with obesity among children: a cohort study

  • 摘要:   目的  探究兒童血漿鳶尾素(Irisin)與肥胖相關指標變化值和新發肥胖的縱向關聯,以及體力活動(physical activity, PA)和靜態行為(sedentary behavior, SB)是否存在調節作用,為兒童肥胖防治工作提供科學依據。  方法  采用整群隨機抽樣的方法,于2017年在廣州市隨機抽取5所小學521名兒童進行問卷調查和體格檢查,并于2019年隨訪。根據基線問卷的PA和SB信息篩選符合標準(SB≥同年齡、性別P75或 < 同年齡、性別P25;且中高等強度PA≥60 min/d或 < 150 min/周)的兒童進行血漿Irisin測量。分別采用多重線性回歸和Logistic回歸進行關聯性分析。  結果  兒童2年內肥胖、超重及肥胖、中心性肥胖的累計發病率分別為2.82%,6.57%,6.81%。兒童血漿Irisin與肥胖相關指標變化值、新發超重肥胖或中心性肥胖的關聯均無統計學意義(P值均>0.05)。以PA水平分層后,低PA組中Irisin水平與體重變化值呈正相關(B=0.229,P=0.03);以SB水平分層后,低SB組中Irisin水平與身高變化值呈正相關(B=0.210,P < 0.05)。PA和SB均對Irisin與體重變化值有調節作用(PPA調節=0.01,PSB調節=0.05)。  結論  PA和SB對兒童血漿Irisin與體重增加值具有調節作用,未發現Irisin與兒童新發超重或肥胖相關。
  • 表  1  Irisin高低水平組研究對象基線調查指標比較(x±s)

    Table  1.   Comparison of baseline survey indicators between high and low irisin levels(x±s)

    組別 人數 年齡/歲 Irisin/(ng·mL-1) 身高/cm 體重/kg BMI/(kg·m-2) 腰圍/cm WHtR MVPA/(min·d-1) SB/(min·d-1)
    低水平組 260 9.29±1.56 7.51±0.88 138.10±12.52 33.46±10.95 17.16±3.22 59.82±9.64 0.43±0.06 65.61±64.43 174.60±112.10
    高水平組 261 9.70±1.55 11.2±2.21 139.90±11.27 33.86±10.20 16.95±2.94 59.17±8.52 0.42±0.05 75.48±68.93 176.50±107.00
    合計 521 9.50±1.57 9.36±2.50 139.00±11.93 33.66±10.57 17.05±3.08 59.49±9.09 0.43±0.05 70.55±66.84 175.54±109.49
    t -3.03 -25.01 -1.80 -0.43 0.76 0.81 1.87 -1.69 -0.19
    P 0.00 < 0.01 0.07 0.67 0.45 0.42 0.06 0.09 0.85
    下載: 導出CSV

    表  2  兒童血漿Irisin水平與肥胖相關指標變化值的關聯性(n=521)

    Table  2.   Relationship of plasma irisin concentrations among children with changes in obesity parameters(n=521)

    肥胖指標 變化值 模型1 模型2
    B值(B值95%CI) P B值(B值95%CI) P
    身高/cm 12.115±3.701 0.086(-0.042~0.214) 0.19 0.109(-0.029~0.247) 0.12
    體重/kg 9.260±4.212 0.037(-0.111~0.186) 0.62 0.076(-0.087~0.240) 0.36
    BMI/(kg·m-2) 1.450±1.410 0.006(-0.043~0.055) 0.81 0.011(-0.043~0.066) 0.68
    腰圍/cm 5.680±4.371 0.070(-0.159~0.298) 0.55 0.078(-0.172~0.329) 0.54
    WHtR 0.000±0.035 0.001(-0.001~0.003) 0.30 0.001(-0.001~0.003) 0.38
    注:模型1調整基線性別、年齡,模型2調整基線性別、年齡、父母文化程度、家庭人均月收入、家族肥胖史、飲食、體力活動時間、靜態行為時間。
    下載: 導出CSV

    表  3  不同PA和SB水平下兒童血漿Irisin水平與肥胖相關指標變化值的分層分析[B值(B值95%CI),n=521]

    Table  3.   Stratified analysis of the relationship of plasma irisin concentrations among children with changes in obesity parameters under different PA or SB status[B(B 95%CI), n=521]

    變量 水平 身高 體重 BMI 腰圍 WHtR
    PA 0.163(-0.030~ 0.356) 0.229(0.024~ 0.435)* 0.046(-0.022~ 0.113) 0.099(-0.212~ 0.409) 0.001(-0.001~ 0.003)
    0.012(-0.205~ 0.229) -0.221(-0.512~ 0.069) -0.054(-0.153~ 0.044) 0.127(-0.375~ 0.630) 0.002(-0.003~ 0.007)
    SB 0.210(0.001~ 0.420)* 0.170(-0.065~ 0.406) 0.009(-0.066~ 0.085) 0.007(-0.286~ 0.301) 0.001(-0.002~ 0.004)
    -0.006(-0.200~ 0.187) -0.011(-0.246~ 0.223) 0.029(-0.051~ 0.108) 0.220(-0.224~ 0.664) 0.002(-0.001~ 0.005)
    ??注:模型調整基線性別、年齡、父母文化程度、家庭人均月收入、家族肥胖史、飲食、體力活動時間、靜態行為時間;*P < 0.05。
    下載: 導出CSV

    表  4  兒童血漿Irisin水平與新發超重肥胖和中心性肥胖的關聯性

    Table  4.   Relationship of circulating Irisin concentrations among children with new-onset obesity or central obesity

    因變量 人數 模型1 模型2
    OR值(OR值95%CI) P OR值(OR值95%CI) P
    肥胖 461 0.83(0.61~1.12) 0.23 0.78(0.52~1.16) 0.21
    超重肥胖 396 0.96(0.81~1.14) 0.65 0.97(0.78~1.20) 0.76
    中心性肥胖 191 0.89(0.67~1.20) 0.45 0.69(0.38~1.27) 0.23
    注: 模型1調整性別、年齡,模型2調整基線性別、年齡、父母文化程度、家庭人均月收入、家族肥胖史、飲食、體力活動時間、靜態行為時間。
    下載: 導出CSV
    客厅的yin乱A片
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  • 收稿日期:  2021-06-18
  • 修回日期:  2021-07-30
  • 網絡出版日期:  2021-10-25
  • 刊出日期:  2021-10-25

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