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兒童青少年體脂肪和瘦體重對心血管危險因素聚集的交互作用

董洋洋 蔡蓉蓉 白玲 周金玉 賈磊娜 丁文清

董洋洋, 蔡蓉蓉, 白玲, 周金玉, 賈磊娜, 丁文清. 兒童青少年體脂肪和瘦體重對心血管危險因素聚集的交互作用[J]. 中國學校衛生, 2021, 42(10): 1555-1559. doi: 10.16835/j.cnki.1000-9817.2021.10.027
引用本文: 董洋洋, 蔡蓉蓉, 白玲, 周金玉, 賈磊娜, 丁文清. 兒童青少年體脂肪和瘦體重對心血管危險因素聚集的交互作用[J]. 中國學校衛生, 2021, 42(10): 1555-1559. doi: 10.16835/j.cnki.1000-9817.2021.10.027
DONG Yangyang, CAI Rongrong, BAI Ling, ZHOU Jinyu, JIA Leina, DING Wenqing. Interaction between fat mass and fat free mass on the aggregation of cardiovascular disease risk factors among children and adolescents[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(10): 1555-1559. doi: 10.16835/j.cnki.1000-9817.2021.10.027
Citation: DONG Yangyang, CAI Rongrong, BAI Ling, ZHOU Jinyu, JIA Leina, DING Wenqing. Interaction between fat mass and fat free mass on the aggregation of cardiovascular disease risk factors among children and adolescents[J]. CHINESE JOURNAL OF SCHOOL HEALTH, 2021, 42(10): 1555-1559. doi: 10.16835/j.cnki.1000-9817.2021.10.027

兒童青少年體脂肪和瘦體重對心血管危險因素聚集的交互作用

doi: 10.16835/j.cnki.1000-9817.2021.10.027
基金項目: 

國家自然科學基金項目 81660565

詳細信息
    作者簡介:

    董洋洋(1993-),女,河北邯鄲人,在讀碩士,主要研究方向為兒童青少年慢性流行病學

    通訊作者:

    丁文清,E-mail:dwqdz@163.com

  • 中圖分類號: R179 R725.4

Interaction between fat mass and fat free mass on the aggregation of cardiovascular disease risk factors among children and adolescents

  • 摘要:   目的  分析銀川市兒童青少年體脂肪(FM)和瘦體重(FFM)對心血管危險因素(CVRFs)聚集的交互作用,為預防兒童青少年心血管疾病的發生提供科學依據。  方法  于2017—2020年使用整群抽樣的方法選取銀川市1 822名12~18歲兒童青少年,進行問卷調查、體格檢查、體成分測定和實驗室檢測。采用二分類Logistic回歸分析FM、FFM與CVRFs聚集的關系,并分析交互作用。  結果  調整性別和年齡后,高FM低FFM組和高FM高FFM組發生CVRFs聚集個數至少為1(CVRFs≥1)的風險是低FM低FFM組的2.01(95%CI=1.46~2.77)、3.64(95%CI=2.66~4.98)倍,CVRFs聚集個數至少為2(CVRFs≥2)的風險分別為1.67(95%CI=1.06~2.63)、4.20(95%CI=2.76~6.38)倍(P值均 < 0.05);FM和FFM存在相乘交互作用,增加CVRFs≥1和CVRFs≥2的風險,調整后的OR值(95%CI)值分別為1.58(1.04~2.40)、1.95(1.12~3.42)(P值均 < 0.05)。  結論  高水平體脂肪和瘦體重對心血管危險因素聚集有相加和相乘交互作用, 增加了心血管危險因素聚集的風險。
  • 表  1  不同組別研究對象基本特征及生化指標比較(x±s)

    Table  1.   Comparison of basic characteristics and biochemical indexes of subjects in different groups(x±s)

    組別 人數 年齡/歲 身高/cm 體重/kg BMI/(kg·m-2) WC/cm WHtR FM/kg FFM/kg
    低FM低FFM 411 14.51±1.73 162.83±6.87 45.85±4.40 17.29±1.34 65.47±3.01 0.40±0.02 7.26±2.36 38.58±4.45
    低FM高FFM 511 15.57±1.35 174.22±5.75 57.98±5.21 19.12±1.50 70.05±3.53 0.40±0.02 6.98±2.06 51.00±4.25
    高FM低FFM 505 15.02±1.81 161.99±5.55 55.31±6.61 21.14±2.50 75.76±6.09 0.47±0.04 16.84±4.61 38.47±3.52
    高FM高FFM 395 15.20±1.51 173.72±6.54 76.80±11.43 25.47±3.42 87.93±9.78 0.51±0.06 21.32±7.88 55.48±6.95
    F/H 33.77 547.09 1 292.82 952.81 1 053.93 864.24 1 021.41 1 412.84
    P < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01
    組別 人數 FPG/
    (mmol·L-1)
    TC/
    (mmol·L-1)
    TG/
    (mmol·L-1)*
    HDL-C/
    (mmol·L-1)
    LDL-C/
    (mmol·L-1)
    SBP/
    mm Hg
    DBP/
    mm Hg
    低FM低FFM 411 4.75±0.60 3.77±0.83 0.87(0.71, 1.07) 1.44±0.36 2.00±0.65 107.85±9.72 66.20±7.18
    低FM高FFM 511 4.79±0.85 3.88±0.91 0.87(0.68, 1.08) 1.44±0.38 2.12±0.74 112.46±10.43 66.63±8.13
    高FM低FFM 505 4.74±0.59 4.08±0.96 0.98(0.77, 1.25) 1.46±0.41 2.22±0.75 108.41±9.81 68.73±7.41
    高FM高FFM 395 4.84±0.62 4.08±0.97 1.10(0.82, 1.45) 1.28±0.32 2.38±0.87 120.14±10.97 70.57±8.32
    F/H 1.81 12.34 116.67 21.61 17.73 126.87 28.48
    P 0.14 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01
    ??注: 1 mm Hg=0.133 kPa;*為M(P25,P75)。
    下載: 導出CSV

    表  2  不同體脂肪和瘦體重分組兒童青少年心血管危險因素及其聚集檢出率比較

    Table  2.   Comparison detection rate of cardiovascular disease risk factors and aggregation based on fat mass and fat free mass subgroups amongchildren and adolescents

    組別 人數 高血糖 高TC血癥 高TG血癥 高LDL-C 低HDL-C 高血壓 CVRFs≥1 CVRFs≥2
    低FM低FFM 411 38(10.2) 28(6.9) 22(5.5) 15(3.7) 31(7.7) 33(8.0) 121(31.9) 37(9.3)
    低FM高FFM 511 65(14.8) 43(8.5) 33(6.6) 27(5.4) 52(10.4) 38(7.4) 185(40.4) 58(11.8)
    高FM低FFM 505 32(7.6) 61(12.3) 80(16.1) 43(8.7) 55(11.1) 57(11.3) 214(47.9) 81(16.9)
    高FM高FFM 395 42(12.2) 51(13.0) 93(23.8) 47(12.0) 94(24.0) 99(25.1) 249(66.2) 112(30.2)
    χ2 12.06 11.94 84.61 24.33 57.14 77.39 98.39 73.14
    P 0.01 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01 < 0.01
    ??注: ()內數字為檢出率/%;血糖及部分血脂指標數據存在缺失值。
    下載: 導出CSV

    表  3  不同模型下兒童青少年體脂肪和瘦體重與心血管危險因素聚集的關系(n=1 822)

    Table  3.   Relationship between fat mass, fat free mass and aggregation of cardiovascular disease risk factors in different models among children and adolescents(n=1 822)

    模型 自變量 CVRFs≥1 CVRFs≥2
    未調整
    OR值(OR值95%CI)
    調整
    OR值(OR值95%CI)
    未調整
    OR值(OR值95%CI)
    調整
    OR值(OR值95%CI)
    1 FM
    ??低 1.00 1.00 1.00 1.00
    ??高 2.39(1.95~2.92)a 2.59(2.07~3.25)a 2.65(2.02~3.47)a 2.56(1.90~3.44)a
    FFM
    ??低 1.00 1.00 1.00 1.00
    ??高 1.76(1.44~2.16)a 1.40(1.08~1.82)b 1.80(1.38~2.34)a 1.90(1.33~2.72)a
    2 低FM低FFM 1.00 1.00 1.00 1.00
    低FM高FFM 1.45(1.09~1.92)b 1.15(0.84~1.57) 1.31(0.85~2.02) 1.29(0.80~2.07)
    高FM低FFM 1.96(1.47~2.60)a 2.01(1.46~2.77)a 1.98(1.31~3.00)b 1.67(1.06~2.63)b
    高FM高FFM 4.18(3.09~5.67)a 3.64(2.66~4.98)a 4.22(2.82~6.32)a 4.20(2.76~6.38)a
    3 FM 1.96(1.47~2.60)a 2.01(1.46~2.77)a 1.98(1.31~3.00)b 1.67(1.06~2.63)b
    FFM 1.45(1.09~1.92)b 1.15(0.84~1.57) 1.31(0.85~2.02) 1.29(0.80~2.07)
    FM×FFM 1.48(0.99~2.21) 1.58(1.04~2.40)b 1.63(0.95~2.81) 1.95(1.12~3.42)b
    ??注: b P < 0.05,a P < 0.01。
    下載: 導出CSV
    客厅的yin乱A片
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  • 收稿日期:  2021-03-12
  • 修回日期:  2021-04-25
  • 網絡出版日期:  2021-10-25
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